The miRNA is a class of small molecule non-coding RNA with a length of about 20-24 bp ,which is transcrip-tion from the endogenous gene .The hairpin structure and the post-transcriptional regulation of gene expression are its typical characteristics .It is suggested that the miRNA play an important control and management role in latent infection and active in-fection in tuberculosis ,and the expression situation of miRNA is also different between latent infection and active infection in tuberculosis .Some studies also found that there are differences in the expression of miRNAs such as miR-155 ,miR-29a ,miR-361-5p ,miR-889 ,miR-576-3p and so on ,as a marker of TB diagnose .