Objective To discuss the efficacy and safty of sodium β-aescin in the treatment of swelling after lower limb fracture operation.Methods From February 2011 to February 2014 in Minda Hospital Affiliated to Hubei Minzu University,patients with swelling limb after lower limb fracture operations were selected as research subjects.The patients were divided into experimental group and control group randomly.The experimental group were received sodiumβ-aescin,the control group were received mannitol.After 4 days treatment,limb circumference,swelling score and pain score in two groups were compared. Results Compared with control group,the limb circumference,swelling score and pain score in experimental group significantly reduced after 4 days treatment(P<0.05 );the therapeutic effect in experimental group was significantly better than that in control group(P<0.05).The incidence of adverse reaction in two groups had no significant difference.Conclusion Application of sodiumβ-aescin on lower limb fracture shows good therapeutic effect.