Objective To evaluate therapeutic effect of Leflunomide combined with glucocorticoids on patients with chronic nephritis.Methods 36 patients with chronic nephritis in Guangyuan Hospital of Traditional Chinese Medicine from January 2012 to October 2013,were randomly divided into two groups:the routine group were treated with conventional therapy;While the theraputic group were treated by leflunomide and glucocorticoid.The tests of urinary protein,serum cretonne and blood urea nitrogen were conducted during treatment in both groups. Results The total effective rate was 88.89 %in the treatment group and 72.2% in the control group.the difference was significant(P<0.05 ).After treatment,measured value of urine protein, serum cretonne and blood urea nitrogen were significantly higher than prior treatment(P<0.05 ).Conclusion The therapeutic effect of leflunomide combined corticosteroid on chronic nephritis is better.