International Journal of Pediatrics 2014;41(3):331-333,336

doi:10.3760/cma.j.issn.1673-4408.2014.03.030

Acute kidney injury and cell cycle regulation

Yunlin SHEN ; Wenyan HUANG

Keywords

Acute kidney injury; Cell cycle; Cell cycle regulatory protein; Cell cycle checkpoint

Country

China

Language

Chinese

Abstract

Acute kidney injury(AKI) has emerged as a major public health problem that leads to decreased survival.In AKI,cell hyperplasia,hypertrophy and apoptosis are related to the cell cycle control.Two supervisory restriction points,G1/S and G2/M checkpoints,are responsible for cell-cycle control.Furthermore,cell cycle regulatory proteins are also involved in the regulation of the cell cycle in AKI.This review focuses on the cell cycle regulation mechanism of AKI.