12 patients with histologically proved wegener's granulomatsis were treated from May 1974 to March 1983.The 3-、 5- and 10- year survival rate S were 83%、64%、50% , respectively. The survival rate was higher in the female. Limited lesions gave a better survival rate than generalized ones.Patients with limited lesions should be treated mainly by radiotherapy alone. The optimal dose was 4000-5500 cGy/4-5.5wk.Patients with generalized lesions should be treated by radiotherapy combined with chemotherapy (CTX 4-8g or CCNU 100mg P.O.), hormone (cortisone 30mg/day),and antibiotics.