China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(12):-

Extraction Technology of Coptis in Shutangluo Capsule

Jing SUN

Keywords

Shutangluo Capsule; coptis; berberine hydrochloride; orthogonal design

Country

China

Language

Chinese

Abstract

Objective: To optimize the preparation procedure of coptis in Shutangluo Capsule.Methods: The orthogonal design(L9(34)) was carried out for the optimum extraction conditions of coptis in Shutangluo Capsule.By determining berberine hydrochloride with HPLC method,the mobile phase of HPLC was CH3CN-0.1%H3PO4-CH3(CH2)10CH2OSO2Na(40:60:0.12g).Results: The best extraction process was as follows: reflux with 6 times of 70% alcohol for two times,every time for 1.5hr.Conclusion: The optimum extraction technology is rational and feasible with high extraction rate of berberine hydrochloride.