Diabetes & Metabolism Journal  2014;38(3):171-180

doi:10.4093/dmj.2014.38.3.171

Ubiquitin Ligases in Cholesterol Metabolism.

Wei JIANG 1 ; Bao Liang SONG

Affiliations

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Keywords

Cholesterol metabolism; Protein homeostasis; Ubiquitin ligases

Country

Republic of Korea

Language

English

Abstract

To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed.