Objective To explore the clinicopathologic features,histological classification,prognosis and diag- nosis of ganglioneuroblasroma (GNB).Methods Histopathologic appearance,immunohistiehemical stainings were observed and analyzed in three cases of GNB.The associated literature were reviewed.Results The characteristics of GNB was detected that there was gangliocytes in component of differentiated neuroblastic tumour ceils.Immunohisti- chemical staining showed the tumor cells were positive for NF,NSE and CgA,and negative for S-100 protein,LCA, CD99 and Syn.Conclusions GNB is an uncommon tumour with poor outcome which composed of gangliocytes and neuroblastoma.To make a histological classification according to age,the ratio of neuroblastic tumour component and the differation of GNB will be very useful in clinical therapy and prognostic evaluation.