Famotidine is a new H2-rceeptor antagonist with high efficieney. we used China -made famotidine 20mg twice a day to treat 80 cases of peptic ulcer. The four-week healing rate reached 71.3%, and total effectiveness was 80%. The abdomen pain disappearance rate reached 41% within a 3-day administration, 69% within a week and 94.8% after a 4-week treatment.As for side effects, only 5 cases manifested mild headache and dizziness. Clinical observation indicates that famotidine is a safe and effective therapy for peptic ulcer