Chinese Journal of Bases and Clinics in General Surgery 2003;0(03):-

Expressions of S-Phase Kinase-Associated Protein 2 and p27 Protein in Gastric Carcinoma and Pericancerous Tissues

Hongliang YAO ; Zhulin YANG ; Yongguo LI ; Guowen LIU

Keywords

Gastric neoplasm S-phase kinase-associated protein 2 p27 protein Immunohistochemistry

Country

China

Language

Chinese

Abstract

Objective To study the expressions of SKP2 and p27 in gastric carcinoma and pericancerous tissues and to detect the relationship between their expressions and clinicopathological features. Methods Forty-nine cases of gastric carcinoma spicemen and 20 cases of tissue adjacent to the carcinoma were cut and made into paraffin-embedded slices. The expressions of SKP2 and p27 were then detected by SP immunohistochemical method. Results The positive expression rate and score of SKP2 were both significantly higher in the gastric carcinoma tissues than those in pericancerous tissues (P