Chinese Journal of Immunology 1985;0(05):-

CD4~+CD25~+/CD4~+CD25~(high) regulatory cells in peripheral blood of cancer patients

Junxia YAO ; Li LIU ; Shiang HUANG

Keywords

Malignancy; CD4+CD25+ regulatory T cells; Flow cytometry

Country

China

Language

Chinese

Abstract

Objective: To investigate the frequencies of CD4+ regulatory T(Treg) cells(CD4+CD25+/CD4+CD25high) in peripheral blood of cancer patients,providing the opportunity to determine whether cancer patients exhibit an expanded CD4+CD25high pool. Methods: The frequency of CD4+CD25+/CD4+CD25high Treg in the peripheral blood of 62 cancer patients and 15 controls was determined by flow cytometry. Results: Compared with those of healthy control, the frequency of CD4+CD25+/CD4+CD25high in the peripheral blood of cancer patients showed a significant increase[(19.61?8.17)%/(4.20?1.90)%,P