Chinese Journal of Immunology 1985;0(05):-

Association between CD4~+CD25~+ regulative T cells and systemic lupus erythematosus disease active stage

Chaojun HU ; Yongzhe LI ; Dinghua LIU ; Dawei TONG ; Shulan ZHANG

Keywords

Systemic lupus erythematosus; CD4+CD25+T-lymphocytes; Peripheral blood

Country

China

Language

Chinese

Abstract

Objective: To investigate the ratios of peripheral blood CD4+CD25+,CD4+CD8+ regulative T cells of systemic lupus erythematosus(SLE) patients, and explore the association with disease active stage,nephropathy,serum anti-ds-DNA antibody,and both IgG and C3 levels. Methods: The percentage of CD4+CD25+T cells and CD4+CD8+T cells of peripheral blood from patients with systemic lupus erythematosus(SLE)(30 females and 7 males),30 rheumatism controls and 30 normal individuals were measured by flowcytometry. Results: Patients with active disease had statisitically lower levels of CD4+CD25+T cells than did normal controls(P