Cancer Research and Clinic 2000;0(01):-

The expression of P-gp, GST-? and TopoⅡ in breast cancer and their clinical significance

Zaixing DENG ; Bei XIE ; Wenju YU

Keywords

Breast neoplasm; Multidrug resistance; P- glycoprote; Glutathione- S- transferase- ?; TopoisomeraseⅡ

Country

China

Language

Chinese

Abstract

Objective To investigate the expression and their clinical significance of P?- glycoprotein (P?- gp), glutathione?- S?- transferase?- ?(GST?- ?)and DNA topoisomerase Ⅱ(TopoⅡ)in breast cancer. Methods The expressions of P?- gp, GST?- ? and TopoⅡ were detected in 60 cases of untreated primary breast cancer by using immunohistochemical S?- P method. Results The positive expression rates of P?- gp, GST?- ? and TopoⅡ in breast cancer were 37.1 %, 66.7 % and 55.0 % respectively. The expression of P?- gp and TopoⅡ had positive correlation with degree of differentiation(P