Journal of Sun Yat-sen University(Medical Sciences) 2009;30(4):437-440,封3

Screening for Mutations of MODY 1-5 Genes in Chinese Families with Early-onset Type 2 Diabetes

Jinhua YAN ; Yunfeng SHEN ; Qiuqiong YU ; Hua LIANG ; Mengyin CAI ; Jianping WENG

Keywords

early-onset type 2 diabetes; gene mutation; maturity-onset diabetes of the young

Country

China

Language

Chinese

Abstract

[Objective] The aim of our study was to seek the mutations in MODY1～5 genes in Chinese population by direct sequencing in probands from families with early-onset type 2 diabetes.[Methods] Variants screening in MODY 1-5 genes were performed by PCR and direct sequencing in 19 probands from early-onset type 2 diabetes families.[Results] We found no mutation but many polymorphisms.There were 6,5,15,1,and 1 variants in MODY 1-5 genes respectively.[Conclusion] Our negative results in MODY genes suggest the genetic heterogeneity of different populations.Mutations in MODY 1-5 genes might not be the cause of diabetes in those 19 families.