Objective:To evaluate the effects of devascularization and shunt operation on portal hypertensive gastropathy.Methods:35 patients were divided into 3 groups:(1)devascularization group(14 patients);(2)shunt group(12 patients);(3)control group(9 patients).Gastroscopy was made preoperatively and postoperatively to observe the changes of gastric mucosa,the apoptotic indexes(AI) were measured by TUNEL and the expression of caspase-3 mRNA was detected by reverse transercription polymerese chain reaction(RT-PCR) method.Results:The AI and expression of caspase-3 mRNA of control group were (2.31?0.11)% and 0.51?0.03 respectively,the AI of other groups was significantly higher than the control group(P