Objective To observe clinical effect of treating chronic sinusitis and nasal polyps with endoscopic sinus surgery combined with Chinese medicine. Methods 65 patients with chronic sinusitis and nasal polyps were randomly divided into a control group and a treatment group. The control group was treated with endoscopic sinus surgery only, and the treatment group was treated with endoscopic sinus surgery combined with Chinese medicine. Results The total effective rate in the treatment group and the control group was 90.9% and 75.0%, respectively. There was a significant dieffference between two groups (P= 0.0416, P<0.05 ). Conclusion The treatment of endoscopic sinus surgery combined with Chinese medicine on chronic sinusitis and nasal polyps is better than endoscopic sinus surgery only.