Objective To study the therapeutic efficaey of matrine on chronic hepatitis B with hyperbilirubinemia.Methods A total of 68 patients were randomly recruited into a treatment and a control groups.Diammonium glycyrrhizinate and glutathione injection were used in both groups.On this basis,the treatment group was treated with matrine injection.while the control group Was treated with Yinzhihuang injection.Both groups were treated for one month.Results The total effective rate was 97%and 85%in the treatment group and the control group respectively,showing significant difference(P<0.01).Indicators such as ALT,AST, TBIL showcd significant difference after treatment compared with the pre-treatment in both groups (P<0.05).Conclusion It is effective of matrine treating chronic hepatitis B with hyperbilirubinemia.