Objective To discuss the therapeutic effect of treating diabetic neurogenic bladder with integrative medicine. Methods 60 patients with diabetic neurogenic bladder were randomly recruited into a treatment group and a control group. The treatment group (30 cases) treated with methylcobalamin, pancreatic kallikrein enteric-coated tablets and Guantong decoction, while the control group (30 cases) was treated with western medicine exclusively. The residual urine volume and symptoms were observed before and after the treatment. Results The treatment group showed significantly better results in improving the symptoms and reducing the residual urine volume than the control group(P＜0.05).Conclusion It is curative to treat diabetic neurogenic bladder with integrative medicine.