Objective To study the method for early treatment and Ⅰ-stage repair of the acute facial and brain injuries and its significance. Methods A retrospective study was performed in 38 cases with acute cranial injury,who underwent early treatment and surgical repair of the cranial bone and/or dura defects with self-tissues,glue material and titanium net depending on individual conditions. Of all,33 cases (87%) received Ⅰ-stage repair. Antibiotic therapy was performed in all the cases after operation. Results All patients recovered with satisfactory regional appearance. No intracranial infection or rhinorrhea of cerebral spinal fluid occurred among them during the follow-up for from six months to 11 years. Conclusion For the acute facial and brain injuries,early treatment and Ⅰ-stage repair based on the injury site and injury severity can attain safe and effective results.