Chinese Journal of Endocrinology and Metabolism 1985;0(02):-

Changes of bone mineral density, bone metabolism indices and Vitamin D receptor content in patients with hyperthyroidism

Xiaoping LIANG ; Jinli WEN ; Wenying ZHOU ; Ziru ZHONG ; Yaying ZHOU

Keywords

Hyperthyroidism; Bone mineral density; Bone metabolism; Receptor, vitamin D

Country

China

Language

Chinese

Abstract

Bone mineral density (BMD) of lumbar spines, femoral neck, Ward′s triangle and greater trochanter was lowered, serum calcium, phosphate, alkaline phosphatase and bone Gla-protein levels were raised, and vitamin D receptor (VDR) contents in lymphocyte was lowered in hyperthyroid patients. Both FT 3 and FT 4 were negatively correlated with BMD, suggesting that hyperthyroidism results in high-turnover type of bone loss which causes the abnormalities of bone metabolic indices and VDR content.