OBJECTIVE To explore the issues and weakness of hospital infection management at clean operating sector . METHODS Effective preventing and controlling measures of hospital infection, sterilization, isolation , and aseptic technique recommended by WHO were utilized in order to improve investigation and management . RESULTS Quality control was formed in the practice process when sterilization and aseptic technique was performed in routine work at clean operating sector. CONCLUSIONS Hospital infection can be prevented and controlled effectively, patients′ safety coefficient can be improved, and operative infection rate can be lowered when the methods stated in this paper are performed strictly.