OBJECTIVE To evaluate the curative effects of surgery combined with early radiotherapy and local injection of hormonal anti-scarring drugs in the treatment of keloid in head and neck region. METHODS 35 patients with keloid were treated with surgery(completely excised and sutured directly or treated with local skin flap).Radiotherapy was applied within 24 hours after operation.A total dose of 20 Gy was administered in ten fractions of 2 Gy every day. Patients who had recurrences were treated with local injection of hormonal anti-scarring drugs.RESULTS After operation,all the wounds were healed by first intention.After 1-4 year follow-up,25 cases(71.43%) were cured without relapse;10 cases(28.57%) showed partial remission.The rate of therapeutic effect was 100%.CONCLUSION Surgical removal combined with local radiation and local injection of hormonal anti-scarring drugs are one of the effective methods in treatment with keloid in head and neck region.