Hanyang Medical Reviews  2006;26(3):70-76

Clinical Strategies to Develop Transplantation Tolerance.

Jong Soo LEE 1 ; Byungsuk KWON ; Hong Rae CHO

Affiliations

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Keywords

Transplantation tolerance; Mixed hematopoietic chimerism; Costimulatory blockade; T cell depletion; Regulatory T cells

Country

Republic of Korea

Language

Korean

Abstract

The development of immunosuprressants has had a significant influence on inhibition of acute allograft rejection. However, long-term graft survival has not been achieved by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using four different approaches; costimulatory blockade, mixed hematopoietic chimerism, T cell depletion, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.