Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(11):-

Effect of Ibudilast on the quality of life of patients with steroid resistant allergic rhinitis:a randomized,double blind,controlled study

Hong LUO ; Xiaoling LIU ; Zezhang TAO ; Nengbing YAN ; Guangzhen PAN ; Yan JIANG ; Ye YU ; Jiangping LI

Keywords

Rhinitis,Allergic,Perennial; Hormones; Drug Resistance; Quality of Life; Questionnaires

Country

China

Language

Chinese

Abstract

OBJECTIVE To assess the effect of Ibudilast on the quality of life (QOL) of patients with steroid resistant allergic rhinitis.METHODS A randomized,double-blind,placebo-controlled study was carried out with Ibudilast in 66 patients with the steroid resistant allergic rhinitis.QOL was measured with Short-Form Health Survey (SF-36) questionnaire (Chinese version).Ibudilast (10rag twice daily,34 patients),placebo (32 patients) was given for 3 weeks. The SF-36 questionnaire was administered at the start of treatment and after 3 weeks of treatment.Sings and Symptom-medication scores were measured daily during the study.RESULTS There were no significant differences between the Ibudilast and placebo group in terms of sings and symptoms or QOL scores before study.After 3 weeks of treatment,symptoms scores were significantly decreased and QOL scores significantly improved in the Ibudilast group compared with those in placebo group (both P