Chinese Journal of Forensic Medicine 1986;0(01):-

An experimental study on substance P in plasma, laryngopharygeal tissue and the lungs in guinea pigs with anaphylactic shock

Jiwei BAI ; Cairong GAO ; Guangmu REN

Keywords

Forensic pathology; Anaphylactic shock; Substance P; Guinea pig; Immunohistochenustry

Country

China

Language

Chinese

Abstract

Objective To explore the pathognomonic findings of anaphylactic shock in forensic medicine. Methods Animal model of anaphylactic shock was developed in guinea pigs. Substance P level in plasma was determined radioimmunoassay, and detected in laryngopharyneal tissue and the lungs by immunohistochemical SABC method followed by image analysis using BI - 2000 image analyzing system. Positive index (PI) was calculated. Results There was a statistically significant difference for substance P concentration in plasma between the guinea pigs with anaphylactic shock (131.01? 18.93pg/?l)and the control animals (87.70 ?7. 60pg/?l) (P