Objective: To observe effect of long-term treatment with removing heat and dampness and regulating collateral method on urinary protein in the patient of chronic nephritis. Methods: 43 cases of chronic nephritis were treated by removing heat and dampness and regulating collateral method for one year and the therapeutic effect was observed. Results: Proteinuria was obviously improved in the patient of chronic nephritis. Conclusion: The removing heat and dampness and regulating collateral method is effective for chronic proteinuria in the patient of chronic nephritis. Tripterygium Wilfordii is beneficial to control of proteinuria.