Journal of Menopausal Medicine  2015;21(2):79-81

doi:10.6118/jmm.2015.21.2.79

G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health.

Mi Jin KIM 1 ; Tae Hee KIM ; Hae Hyeog LEE

Affiliations

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Keywords

Estradiol; Estrogens; Genomics; GTP-binding proteins

Country

Republic of Korea

Language

English

Abstract

Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.