Biomolecules & Therapeutics  2016;24(3):305-311

doi:10.4062/biomolther.2015.131

Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation.

Won Serk KIM 1 ; Ikyon KIM ; Wang Kyun KIM ; Ju Yeon CHOI ; Doo Yeong KIM ; Sung Guk MOON ; Hyung Keun MIN ; Min Kyu SONG ; Jong Hyuk SUNG

Affiliations

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Keywords

Mitochondria-Targeted vitamin E; UVB protection; Fibroblast; HaCaT; Collagen

Country

Republic of Korea

Language

English

Abstract

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.