Journal of Chinese Physician 2000;0(12):-

Detection of Telomerase Activity in Gastric Mucosa by Improved TRAP Assay

Yong WU ; Zhengyan CHEN

Keywords

Gastric tumor,cancer; Telomerase; Laboratory diagnosis; Gastric mucosa biopsy

Country

China

Language

Chinese

Abstract

Telomerase activity in 43 biopsy of gastric mucosa was detected with the modified telomeric repeat amplification protocol(TRAP) assay to elucidate pathogenesis of gastric cancer.The detected positive rates were as follows:87%(20/23) in gastric cancer,28 6%(2/7) in moderate and non-typical gastritis ,0%(0/10 in atrophic and superficial gastritis,respectively.These results suggest that the detection of telomerase activity may play a significant role in the diagnosis of gastric cancer.