International Neurourology Journal  2011;15(4):184-191

Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome.

Jayoung KIM 1 ; Michael R FREEMAN

Affiliations

+expand

Keywords

Human antiproliferative factor APF; Interstitial Cystitis; Signal transduction

Country

Republic of Korea

Language

English

Abstract

A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address the underlying mechanism whereby APF regulates cellular responses in the bladder epithelium. A summary of recent literature is provided, and is focused on signal transduction pathways and networks that are responsive to APF.