OBJECTIVE: To properly evaluate the conditions of clinical practice of quinolone antibacterial agents. To provide data for clinical medicine and to guide rational drug use. METHODS: 237 cases with adverse reactions induced by quinolone antibacterial agents reported in demestic literatures issued from 1985 to 1997 were collected and statistically ana- lyzed. RESULTS: The general rule and characteristics of occurrence of adverse reactions resulted from quinolones have been summarized. CONCLUSION: The indications for clinical use of quinolones should be handled strictly, especially in children, so as to avoid the abuse of drug.