Objective To study the hemorheology,platelet-activating and hemostasis of severe asphyxiated newborns. Methods Erythrocyte filtration index(IF) ,granule membrane glycoprotein (GMP-140),D-dimer(DD) and yon Willebrand factor(vWF) were measured in 60 severe asphyxiated term newborns and 20 healthy term newborns. The effect of platelet-activating-factor (PAF) antagonist-EGb761 were also obserred. 60 term newborns with severe asphyxia were divided into two groups :treatment group(n= 30) and control group(n = 30). Results During the first day of life the IF,GMP-140,vWF and DD of the severe asphyxiated newborns increased significantly compared with those of healthy newborns(P0.05). Conclusion 1. Severe asphyx iated newborns vary in hemorheology,platelet-activating and hemostasis,which leads to disturbance of microcirculation and organ injury. 2. PAF plays a role in the pathophysiologic process, and PAF antagonist can improve the microcirculation of severe asphyxiated newborns.