This paper reports the results of surgical management of 38 patients with chronic gasric and duodenal ulcer complicted with mycotic infection.This disease was easily be misdiagnosed as gas- tric carcinoma,especially when a mass can be palpated in the upperabdomen.Gastroscopical biopsy was the most effective method of diagnosis.When the ulcer complicated with mild mycotic infection,it can be treated by anti-mycotic drugs.But if the ulcer is large and deep,or complicated with hemorrhage,perforation or malignancy,the treatment of choice is surgery.Before operation,using anti-mycotic drugs to prevent the occurrence of mycotic sepsis must be consider- ated.During operation,if malignancy is suspected,frozen section should be taken.