Journal of Kunming Medical University 1989;0(01):-

Toxicological and General Pharmacological Studies of Coleus forskohlii Oral Solution

Xinhua WANG

Keywords

Coleus forskohlii; Oral solution; Mice; Acutetoxicity; Rats; Subchronic toxicity; Rabbits; General pharmacologic effects

Country

China

Language

Chinese

Abstract

Coleus forskohlii oral solution is a composite preparation containing several effective constituents of the plant, such as isoforskolin, 1-acetylforskolin etc.Following ig administration of the oral solution equivalent to≤35 g (raw herb)/kg to mice, neither toxic reaction nor death was observed. After the oral solution 30, 15, 10 g/(kg?d)?60 ig to rats, their appearance, body weight, and hematological, biochemical and pathological investigations were basically normal. In anesthetized rabbits intraduodenally administered the oral solution≤10g/kg, the respiration, airway secretion, blood pressure, ECG and EEG did not change significantly.These results indicate that Coleus forskohlii oral solution is a quite safe preparation.