Tianjin Medical Journal 2017;45(4):428-431

doi:10.11958/20170042

Research progress of CX3CL1-CX3CR1 and the pathogenesis of sepsis

Dingwei PENG ; Yueqiu QIN ; Pinhu LIAO

Keywords

sepsis; chemokine CX3CL1; receptors; CXCR; review

Country

China

Language

Chinese

Abstract

Sepsis has poor prognosis, and its pathogenesis is not clear. Chemokine CX3CL1 (Fractalkine, FNK) has many functions such as chemotaxis, adhesion and mediate immune injury. CX3CR1 is the only receptor of CX3CL1 and participates in the development of sepsis. Here we review the structure, biological function and possible mechanism of CX3CL1 and CX3CR1 in the pathogenesis of sepsis.