Laboratory Medicine Online  2017;7(4):196-200

doi:10.3343/lmo.2017.7.4.196

A Case of Acute Promyelocytic Leukemia with Co-existence of BCR-ABL1 and PML-RARA Rearrangements Detected by PCR.

Gyu Dae AN 1 ; Hyeon Ho LIM ; Kwang Sook WOO ; Kyeong Hee KIM ; Jeong Man KIM ; Sung Hyun KIM ; Jin Yeong HAN

Affiliations

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Keywords

Acute promyelocytic leukemia; PML-RARA; BCR-ABL1

Country

Republic of Korea

Language

Korean

Abstract

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by PML-RARA fusion and specific morphology. The BCR-ABL1 rearrangement is mainly observed in patients with chronic myeloid leukiemia (CML). However, it is also found in patients with acute lymphoblastic leukemia (ALL) and in a few patients with AML. However, it is very rarely observed in patients with APL. Here, we report a case of APL with t(15;17) and co-existence of PML-RARA and BCR-ABL1. Further study with more cases is warranted to find the right treatment and prognostic significance.