Experimental & Molecular Medicine  2014;46(9):e112-

doi:10.1038/emm.2014.51

MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2.

Zhenshun CHENG 1 2 ; Rongli MA ; Weijun TAN ; Li ZHANG

Affiliations

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Country

Republic of Korea

Language

English

Abstract

MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.