PURPOSE: This study was designed to construct a structural model for explaining model health-related quality of life in acquired people with physical disabilities. METHOD: The hypothetical model of this study was consisted of 6 latent variables and 14 observed variables. Exogenous variables included in this model were physical status and economical level. Endogenous variables were social attitudes, family function, self-esteem, and health-related quality of life. Data were collected from 226 acquired people with physical disabilities residing in Seoul and Kyunggi-do from January to February, 2005. The collected data were analyzed using SAS 8.2 version and LISREL 8.32 version program. RESULTS: The results of the fitness test of the modified model were follow as; chi-square=67.479 (df=50, p=.05), GFI= .959, AGFI=.914, SRMR=.049, NFI=.961, NNFI=.979, CN=249.244. Health-related quality of life was influenced directly by physical status, economic level, and social attitudes and accounted for 88.8% of the variance by these factors. CONCLUSION: These results suggest that physical status is the most significant effect on health-related quality of life, and social attitudes and economic level are important factors having influences on health- related quality of life. Therefore improving physical status and economic level, and modifying negative attitudes are necessary to increase health-related quality of life of acquired people with acquired physical disabilities.