Objective:To evaluate therapeutic effect and safety of rosuvastatin on patients with hyperlipidemia com‐plicated hyperuricemia .Methods :A total of 88 patients with hyperlipidemia complicated hyperuricemia ,who were hospitalized in our hospital ,were selected ,randomly and equally divided into rosuvastatin group (10 mg/d) and atorvastatin group (20 mg/d) ,both groups were treated for eight weeks .Changes of levels of blood lipids and serum uric acid (SUA) were observed and compared between two groups before and after treatment .Results:Compared with before treatment ,after eight -week treatment ,there were significant reductions in levels of blood lipids (ex‐cept high density lipoprotein cholesterol ) and SUA in both groups , P<0.01 all;compared with atorvastatin group after treatment ,there were significant reductions in levels of total cholesterol [ (4.87 ± 0.47) mmol/L vs .(4.48 ± 0.53) mmol/L] in rosuvastatin group (P=0.04) ,and there was no significant difference in SUA level between two groups , P>0.05. There were all no more serious side effects in both groups .Conclusion:While reducing blood lipid levels ,rosuvastatin can also reduce serum uric acid level in patients with hyperlipidemia ,and it possesses good safety and tolerance .