Kidney Research and Clinical Practice  2015;34(2):117-119

doi:10.1016/j.krcp.2014.10.008

Fibrillary glomerulonephritis combined with chronic inflammatory demyelinating polyneuropathy.

Woo Kyung SUNG 1 ; Jin Uk JEONG ; Ki Tae BANG ; Jong Ho SHIN ; Ji Hyung YOO ; Nak Min KIM ; Jun Hyung PARK ; Joo Heon KIM

Affiliations

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Keywords

Fibrillary glomerulonephritis; Monoclonal gammopathy; Polyneuropathy

Country

Republic of Korea

Language

English

Abstract

A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12-20 m nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin (Ig)G, IgM, IgA, C3, and kappa light chains in the capillary walls and mesangial areas. A Congo red stain for amyloid was negative. Electromyography and nerve conduction velocity examinations results were compatible with the presence of demyelinating polyneuropathy. This case showed a rare combination of FGN, without Ig deposition, and MGUS combined with chronic inflammatory demyelinating polyneuropathy (CIDP).