Korean Journal of Blood Transfusion  2013;24(3):207-216

Platelet Additive Solutions.

Jin Hyuk YANG 1 ; So Yong KWON ; Juyeon LEE ; Yong Hun JEE ; Myunghan KIM

Affiliations

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Keywords

Platelet additive solution; Plasma; Buffy coat method

Country

Republic of Korea

Language

Korean

Abstract

Storage of platelet concentrates in platelet additive solution (PAS) with plasma removal has many advantages, including reduction of allergic reactions, contributing to the available plasma pool for fractionation or transfusion, and employment of pathogen reduction technology. In order to decrease platelet activation for improvement of in vivo viability, PAS should be designed for optimization of aerobic metabolism using compounds such as glucose, acetate, citrate, phosphate, and electrolytes. After a thorough discussion, particularly on the efficacy and regulations, use of the buffy coat method as well as application of a new generation of PAS may likely be the future direction of platelet storage in Korea.