Acute ischemic stroke has already become common cause of death in our country.Until now,the intravenous thrombolysis therapy produces a limited therapeutic efficacy in patients with acute ischemic stroke,because the recanalization rate is very low in patients with large vessel occlusion,especially with interal carotid artery occlusion.As a novel modality of primary treatment,endovascular mechanical recanalization using clot removal has become a noticeably efficient intervention and a hot research focus of acute ischemic stroke.In this paper,we reviewed recent large multicenter trials of endovascular mechanical recanalization in the world.