Chinese Journal of Rehabilitation Theory and Practice 2016;22(10):1171-1174

doi:10.3969/j.issn.1006-9771.2016.10.013

Mechanism of Nuclear Factor-κB in Skeletal Muscle Atrophy during Prevention and Treatment of Exercise in Patients with Chronic Obstructive Pulmonary Disease (review)

Weibing WU ; Jingxin LIU ; Xiaodan LIU ; Zhenwei WANG ; Juntao YAN

Keywords

chronic obstructive pulmonary disease; skeletal muscle atrophy; exercise; nuclear factorκB; review

Country

China

Language

Chinese

Abstract

Chronic obstructive pulmonary (COPD) has significant extra pulmonary effects, which could induce atrophy of peripheral skeletal muscle and respiratory muscles, and significantly influence the respiratory function and quality of life. Muscle nuclear factor (NF)-κB activation plays a key role in the skeletal muscle atrophy. This article discussed the potential mechanisms on how NF-κB signaling pathway increasing protein breakdown and reducing muscle regeneration. On this basis, we explored the role of NF-κB in skeletal muscle at-rophy in patients with COPD during exercise.