Objective To investigate the effect of meridian-warming and unblocking acupuncture and moxibustion on the quality of life in patients with osteoporotic vertebral body compression fractures. Method Two hundred and eighty patients meeting the criteria of osteoporotic vertebral body compression fractures were enrolled and randomly allocated to treatment and control groups. The treatment group received meridian-warming and unblocking acupuncture and moxibustion and the control group, complex treatment of Western medicine. The Visual Analogue Scale (0-10 marks) score and the SF-36 score were recorded before and after treatment. The clinical therapeutic effects were evaluated. Result The pain score was decreased, the SF-36 score was increased and the clinical therapeutic effect was improved more in the treatment group than in the control group (P<0.05). Conclusion Meridian-warming and unblocking acupuncture and moxibustion helps to relieve the pain and improve the quality of life in osteoporosis patients.