Practical Oncology Journal 2016;30(5):458-462

doi:10.11904/j.issn.1002-3070.2016.05.015

The role of FoxM1 in the development and treatment of breast cancer

Huiying LI ; Jingshu GENG

Keywords

FoxM1; Transcription factor; Breast cancer; Therapy

Country

China

Language

Chinese

Abstract

FoxM1 is a specific transcription factor related to proliferation .Previous studies have found that FoxM1 can enhance the proliferation ,metastasis and invasion of cancer cells ,and play a crucial role in canc-er.Recent studies indicate that the abnormal expression of FoxM 1 plays an important role in breast cancer ,and its overexpression is negatively correlated with the overall survival of patients .For the early diagnosis of breast canc-er,clinical prognosis and study on combination therapy provides a new direction .This article reviews the relation-ship between FoxM1 and breast cancer .