Chinese Journal of Nuclear Medicine and Molecular Imaging 2016;36(5):470-473

doi:10.3760/cma.j.issn.2095-2848.2016.05.022

Radionuclide molecular probe for the diagnosis and target therapy of malignant melanoma

Hongyan FENG ; Xiaoli LAN ; Yongxue ZHANG

Keywords

Melanoma; Diagnosis; Molecular targeted therapy; Molecular probes; Isotope labeling; Trends

Country

China

Language

Chinese

Abstract

Early diagnosis and accurate staging are important for planning therapeutic intervention to improve outcomes in patients with malignant melanoma (MM).Noninvasive molecular imaging has been extensively studied in cancer diagnosis,staging,therapeutic evaluation,and prognosis.Several radiopharmaceuticals have been developed to diagnose and treat MM,such as monoclonal antibodies,melanocortin receptors,benzamide (BZA) and BZA analogs.In this review,the characteristics and limitations of these radionuclide molecular probes are summarized and discussed.