Chinese Journal of Gastroenterology 2016;21(10):626-628

doi:10.3969/j.issn.1008-7125.2016.10.011

Progress in Research on Guanylyl Cyclase C in Diagnosis and Treatment of Colorectal Cancer

Zhendong YAO ; Min XU

Keywords

Guanylate Cyclase C; Colorectal Neoplasms; Recurrence; Neoplasm Metastasis; Diagnosis; Therapy

Country

China

Language

Chinese

Abstract

Guanylyl cyclase C( GCC)is a specific intestinal tissue polypeptide expressed in intestinal epithelial cells,and is also expressed in colorectal cancer cell line and primary and metastatic colorectal cancer. Studies have indicated that level of GCC mRNA in blood could contribute to the early detection of colorectal cancer metastasis and recurrence,and is beneficial to the formulation of therapeutic regimen and follow-up. This article reviewed the progress in research on GCC in diagnosis and treatment of colorectal cancer.