Journal of International Oncology 2016;43(11):861-864
doi:10.3760/cma.j.issn.1673-422X.2016.11.016
Chemotherapy drug resistance mechanisms of hepatocellular carcinoma to arsenic trioxide
Yaoting CHEN ; Xiaojun HU ; Dan LI ; Hong SHAN
Keywords
Liver neoplasms; Arsenicals; Drug resistance,neoplasm; Molecular targeted therapy
Country
China
Language
Chinese
Abstract
Many studies have proven that arsenic trioxide (As2 O3 )as a single agent is not effective against hepatocellular carcinoma (HCC).Many scholars believe that chemotherapy drug resistance of HCC to As2 O3 is the most important reason.The underlying drug resistance mechanism of HCC cells to As2 O3 remains unclear.Studies show that potential mechanism may be tightly associated with As2 O3 pharmacokinetics and properties of HCC tissues and complex molecular biology.
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