Military Medical Sciences 2016;40(10):847-850

doi:10.7644/j.issn.1674-9960.2016.10.017

Research progress in Clostridium difficile tcdC gene

Jianxia WANG ; Hongwei WANG ; Xiaoyan FENG ; Dazhi JIN

Keywords

Clostridium difficile; pathogenicity locus; tcdC gene; virulence

Country

China

Language

Chinese

Abstract

TcdA and B toxins secreted by Clostridium difficile( CD) are two important causes of diseases in organisms. The expression of tcdA and tcdB genes is regulated by a few factors located in the pathogenicity locus ( PaLoc) .Studies have indicated that the tcdC gene is likely to act as a negative regulator of toxin gene expression.So far, it has been debatable whether tcdC gene is regarded as a negative regulator.The mechanism of tcdC gene in pathogenesis remains unclear.In this paper, the structure and function of the tcdC gene are summarized, which will help study the mechanism of tcdC gene and obtain optimal drug targets.