Military Medical Sciences 2016;40(10):851-855

doi:10.7644/j.issn.1674-9960.2016.10.018

Research progress in benchmark dose in risk assessment of long-team exposure toxicity

Hui PENG ; Qiaofang LI ; Jian YIN ; Tingfen ZHANG ; Jiabin GUO ; Yimei WANG ; Shuangqing PENG

Keywords

benchmark dose; no-observed-adverse-effect level; risk assessment; long-term exposure toxicity

Country

China

Language

Chinese

Abstract

The purpose of risk assessment is to evaluate the permissible exposure level under specific risk factors.To extrapolate the human acceptable daily intake (ADI) and/or reference dose (RfD), the traditional method uses the no-observed-adverse-effect level ( NOAEL ) to quantify toxicity after being divided by uncertainty factor.There are many limitations with NOAEL method in safety evaluation,for it relies too much on experimental design.Benchmark dose ( BMD) approach is a more reliable method with many advantages.BMD approach and its analysis software, the advantages of BMD over NOAEL, the application and methodological perfection in risk assessment of long-team exposure toxicity are presented in this review.